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The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes.

Authors
  • And 26 more
Type
Published Article
Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
1525-4135
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
41
Issue
3
Pages
352–360
Identifiers
PMID: 16540937
Source
Medline
License
Unknown

Abstract

Based on the calculated genetic barrier, the rate of drug resistance development may be similar for different HIV-1 subtypes. Because of differences in minor protease substitutions, protease inhibitor resistance could be enhanced in particular subtypes once the relevant major substitutions are selected.

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