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The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes.

Authors
  • van de Vijver, David A
  • Wensing, Annemarie M J
  • Angarano, Gioacchino
  • Asjö, Birgitta
  • Balotta, Claudia
  • Boeri, Enzo
  • Camacho, Ricardo
  • Chaix, Marie-Laure
  • Costagliola, Dominique
  • De Luca, Andrea
  • Derdelinckx, Inge
  • Grossman, Zehava
  • Hamouda, Osamah
  • Hatzakis, Angelos
  • Hemmer, Robert
  • Hoepelman, Andy
  • Horban, Andrzej
  • Korn, Klaus
  • Kücherer, Claudia
  • Leitner, Thomas
  • And 26 more
Type
Published Article
Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2006
Volume
41
Issue
3
Pages
352–360
Identifiers
PMID: 16540937
Source
Medline
License
Unknown

Abstract

Based on the calculated genetic barrier, the rate of drug resistance development may be similar for different HIV-1 subtypes. Because of differences in minor protease substitutions, protease inhibitor resistance could be enhanced in particular subtypes once the relevant major substitutions are selected.

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