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Calculated conformations of sialyl-Le(x)- and sialyl-Le(a)-lactones.

Authors
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry
0968-0896
Publisher
Elsevier
Publication Date
Volume
2
Issue
11
Pages
1261–1266
Identifiers
PMID: 7757422
Source
Medline

Abstract

The minimum energy conformations of the four sterically reasonable SLe(x) and SLe(a) lactones were calculated using the molecular mechanics force-field MM2(91). The tetrasaccharide lactone involving the 3- and 2-position of the Gal moiety was found to be more stable than the 3,4-lactone both for SLe(x) and SLe(a).

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