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Calcium signaling in cognition and aging-dependent cognitive decline.

Authors
  • Oliveira, Ana M M
  • Bading, Hilmar
Type
Published Article
Journal
BioFactors
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2011
Volume
37
Issue
3
Pages
168–174
Identifiers
DOI: 10.1002/biof.148
PMID: 21698696
Source
Medline
License
Unknown

Abstract

Calcium-dependent signals are key triggers of the molecular mechanisms underlying learning and memory and dysregulation of calcium homeostasis in the aging brain has been proposed to underlie aging-dependent cognitive decline. Mechanisms triggered by calcium in neurons include activity-dependent activation of transcription responsible for the synthesis of molecules underlying the long-term changes of neuronal function. Effectors of calcium signaling with a primordial role in transcription regulation are calcium signal-regulated transcription factors. In this review, we summarize the current knowledge of the contribution of key calcium signal-regulated transcription factors, namely CREB, NFAT, and DREAM, to memory formation. We further describe evidence for dysregulation of the activity of these factors during aging.

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