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Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species.

Authors
  • Aihara, Kinue
  • Byer, Karen J
  • Khan, Saeed R
Type
Published Article
Journal
Kidney international
Publication Date
Oct 01, 2003
Volume
64
Issue
4
Pages
1283–1291
Identifiers
PMID: 12969146
Source
Medline
License
Unknown

Abstract

Brushite crystals are injurious to cells of both the proximal tubules as well as collecting ducts. Injury is mediated by reactive oxygen species. We propose that CaP crystals can independently interact with renal epithelium, promote sites for crystal attachment, and then either grow into mature CaP stones or create sites for CaOx crystal nucleation, retention, and stone development.

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