Affordable Access

deepdyve-link
Publisher Website

Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis

Authors
  • Som, Avik1, 2, 1, 2
  • Raliya, Ramesh3, 3
  • Paranandi, Krishna1, 1
  • High, Rachel A4, 4
  • Reed, Nathan3, 3
  • Beeman, Scott C1, 1
  • Brandenburg, Matthew1, 1
  • Sudlow, Gail1, 1
  • Prior, Julie L1, 1
  • Akers, Walter1, 5, 1, 5
  • Mah-Som, Annelise Y6, 6
  • Habimana-Griffin, Lemoyne1, 2, 1, 2
  • Garbow, Joel1, 1
  • Ippolito, Joseph E1, 7, 1, 7
  • Pagel, Mark D4, 4
  • Biswas, Pratim3, 3
  • Achilefu, Samuel1, 2, 8, 9, 1, 2, 8, 9
  • 1 Mallinckrodt Institute of Radiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
  • 2 Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO 63130, USA
  • 3 Department of Energy, Environmental, Chemical Engineering, Washington University in St Louis, St Louis, MO 63130, USA
  • 4 Cancer Biology Graduate Interdisciplinary Program, University of Arizona Cancer Center, Tucson, AZ 54724, USA
  • 5 Department of Biochemistry & Biophysics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
  • 6 Imaging & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
  • 7 Department of Pediatrics, Division of Rheumatology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
  • 8 Department of Genetics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
  • 9 Department of Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
Dec 06, 2018
Volume
14
Issue
2
Pages
169–182
Identifiers
DOI: 10.2217/nnm-2018-0302
PMID: 30730790
PMCID: PMC6369564
Source
PubMed Central
Keywords
License
Unknown

Abstract

Aim: CaCO3 nanoparticles (nano-CaCO3) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO3 to noninvasively monitor pH modulation and subsequent tumor response. Materials & methods: We synthesized ferromagnetic core coated with CaCO3 (magnetite CaCO3). Magnetic resonance imaging (MRI) was used to determine the biodistribution and pH modulation using murine fibrosarcoma and breast cancer models. Results: Magnetite CaCO3-MRI imaging showed that nano-CaCO3 rapidly raised tumor pHe, followed by excessive tumor-associated acid production after its clearance. Continuous nano-CaCO3 infusion could inhibit metastasis. Conclusion: Nano-CaCO3 exposure induces tumor metabolic reprogramming that could account for the failure of previous intermittent pH-modulation strategies to achieve sustainable therapeutic effect.

Report this publication

Statistics

Seen <100 times