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Calcium carbonate end-capped, folate-mediated [email protected] core-shell nanocarriers as targeted controlled-release drug delivery system.

Authors
  • Liu, Min-Chao1
  • Liu, Bing2
  • Chen, Xian-Li3
  • Lin, Hui-Chao1
  • Sun, Xiang-Yu1
  • Lu, Jia-Zheng2
  • Li, Yan-Yu1
  • Yan, Si-Qi1
  • Zhang, Lu-Yong2
  • Zhao, Ping1
  • 1 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China. , (China)
  • 2 2 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China. , (China)
  • 3 3 Medical College of Shaoguan University, Guangdong, China. , (China)
Type
Published Article
Journal
Journal of Biomaterials Applications
Publisher
SAGE Publications
Publication Date
Mar 01, 2018
Volume
32
Issue
8
Pages
1090–1104
Identifiers
DOI: 10.1177/0885328217752994
PMID: 29357775
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Magnetic mesoporous silica nanospheres (MMSN) were prepared and the surface was modified with cancer cell-specific ligand folic acid. Calcium carbonate was then employed as acid-activated gatekeepers to cap the mesopores of the MMSN, namely, MMSN-FA-CaCO3. The formation of the MMSN-FA-CaCO3 was proved by several characterization techniques, viz. transmission electron microscopy, zeta potential measurement, Fourier transform infrared spectroscopy, BET surface area measurement, and UV-Vis spectroscopy. Daunomycin was successfully loaded in the MMSN-FA-CaCO3 and the system exhibited sensitive pH stimuli-responsive release characteristics under blood or tumor microenvironment. Cellular uptake by folate receptor (FR)-overexpressing HeLa cells of the MMSN-FA-CaCO3 was higher than that by non-folated-conjugated ones. Intracellular-uptake studies revealed preferential uptake of these nanoparticles into FR-positive [FR(+)] HeLa than FR-negative [FR(-)]A549 cell lines. DAPI stain experiment showed high apoptotic rate of MMSN-FA-DNM-CaCO3 to HeLa cells. The present data suggest that the CaCO3 coating and folic acid modification of MMSN are able to create a targeted, pH-sensitive template for drug delivery system with application in cancer therapy.

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