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Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity.

Authors
Type
Published Article
Journal
Clinical Transplantation
1399-0012
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
22
Issue
1
Pages
1–15
Identifiers
DOI: 10.1111/j.1399-0012.2007.00739.x
PMID: 18217899
Source
Medline
License
Unknown

Abstract

Calcineurin inhibitors are associated with significant nephrotoxicity and chronic kidney damage. Minimization is associated with a modest increase in renal function, but persistent damage is observed on biopsies as long as the CNIs are continued. Avoidance is hampered by lack of experience and possible sirolimus-induced side effects. CNI withdrawal may be the best option by delivering CNIs during the early period of immunologic graft injury and then converting them to less nephrotoxic agents before significant renal damage occurs.

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