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Calcification in the human lens.

Authors
  • Fagerholm, P
  • Philipson, B
  • Carlström, D
Type
Published Article
Journal
Current eye research
Publication Date
Jan 01, 1981
Volume
1
Issue
11
Pages
629–633
Identifiers
PMID: 7346235
Source
Medline
License
Unknown

Abstract

A calcified cataractous lens from a 12 year old boy suffering from chronic uveitis was analysed using a microradiographic technique, X-ray crystallography and transmission electron microscopy. A 0.2 mm thick shell of calcified tissue was found in the subcapsular cortex. The mineral consisted of well-crystallized hydroxyapatite with a random orientation of the crystals. The underlying cortex consisted of a fibrous matrix containing collagen fibers. In the matrix, single or groups of epitheloid cells and fibroblast-like cells were found. Membrane-enclosed vesicles were found scattered in the matrix. The content of these vesicles had a wide range of electron density. A cell-induced mechanism for calcification is suggested.

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