Affordable Access

cagA, vacA and iceA virulence genes of Helicobacter pylori isolates of children in Finland.

Authors
  • Karhukorpi, J
  • Yan, Y
  • Kolho, K L
  • Rautelin, H
  • Lahti, M
  • Sirviö, A
  • Riipinen, K
  • Lindahl, H
  • Verkasalo, M
  • Fagerholm, R
  • Karttunen, R
Type
Published Article
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Publication Date
Oct 01, 2000
Volume
19
Issue
10
Pages
790–793
Identifiers
PMID: 11117646
Source
Medline
License
Unknown

Abstract

cagA, vacA s and m genotypes and iceA alleles were analyzed from Helicobacter pylori strains isolated from 17 Finnish children and 32 children of non-Finnish origin living in Finland. Twelve children in the latter group were eastern European and 15 were of African origin. Only three children of non-Finnish origin were born in Finland. The vacA sla subtype was more prevalent in the isolates from Finnish children than African children (76% vs. 7%, P<0.001); vacA s1b frequencies were 5% and 67%, respectively (P<0.001). The iceA1 allele was significantly more prevalent in African than Finnish isolates (93% vs. 35%, P< 0.01). Considerable variation was noted in the frequency of vacA s1 subtypes and iceA alleles in children originating from different geographic regions, but the geographic variation of s1 subtypes resembled that described in other reports.

Report this publication

Statistics

Seen <100 times