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Caffeine ingestion alters central hemodynamics following aerobic exercise in middle-aged men.

Authors
  • Harber, Matthew P1
  • McCurry, Allison2
  • Carlini, Nicholas2
  • Kistler, Brandon3
  • Fleenor, Bradley S2
  • 1 Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, IN, 47306, USA. [email protected]
  • 2 Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, IN, 47306, USA.
  • 3 Nutrition and Dietetics, Ball State University, Muncie, IN, USA.
Type
Published Article
Journal
European Journal of Applied Physiology and Occupational Physiology
Publisher
Springer-Verlag
Publication Date
Feb 01, 2021
Volume
121
Issue
2
Pages
435–443
Identifiers
DOI: 10.1007/s00421-020-04521-3
PMID: 33098463
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To examine the acute influence of caffeine on post-exercise central blood pressures, arterial stiffness, and wave reflection properties. In a double-blind randomized placebo-controlled crossover study design, ten middle-aged males (55 ± 5 year) completed two exercise trials after ingestion of caffeine (400 mg) or placebo. Measurements were taken before and 30 min post-ingestion via cuff-based pulse wave analysis (PWA) and carotid-femoral pulse wave velocity (PWV). Participants performed a 40-min cycling bout at 70% HRmax with matched workloads between trials. PWA and PWV were reassessed 30 min post-exercise. Prior to exercise, compared to placebo, caffeine increased brachial systolic blood pressure (bSBP) (+ 12.3 ± 2.4 mmHg; p = 0.004), brachial diastolic blood pressure (bDBP) (+ 7.7 ± 0.9 mmHg; p = 0.011), central systolic blood pressure (cSBP) (+ 11.1 ± 2.1 mmHg; p = 0.005) and central diastolic blood pressure (cDBP) (+ 7.6 ± 1.0 mmHg; p = 0.012). PWV was higher 30 min after pill ingestion (p = 0.021 for time) with a trend for a greater increase in caffeine (p = 0.074 for interaction). bSBP (p = 0.036) and cSBP (p = 0.007) were lower after exercise but remained higher (both p < 0.001) in caffeine compared to placebo. PWV remained higher (p = 0.023) after exercise in caffeine compared to placebo but was not influenced by exercise. At rest, augmentation pressure (AP) and index (AIx) were not influenced by caffeine ingestion. Conversely, AIx was lower (p = 0.009) after exercise in placebo only. In healthy and active middle-aged men, pre-exercise caffeine ingestion led to higher central and peripheral systolic blood pressures, PWV and AIx at 30 min post-exercise, indicating an increased left ventricular workload which may have implications for cardiovascular event risk.

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