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Time hierarchy in enzymatic reaction chains resulting from optimality principles

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
129
Issue
2
Identifiers
DOI: 10.1016/s0022-5193(87)80012-7
Disciplines
  • Biology
  • Computer Science

Abstract

Several optimality principles reasonable for the evolution of enzyme reaction chains are formulated, considering the kinetic parameters of the enzymes to be variables. The solutions of these parametric programming problems are studied for the case of linear kinetics and turn out to be not unique in every case. The investigations are confined to stationary states. The net flux through the chain is considered a fixed parameter. The optimality criteria concern the osmotic pressure caused by the intermediates, various relaxation times, largest time scale, and controllability. They all yield distinct time hierarchies. The influence of a constraint concerning the sum of intermediate concentrations is studied. Various combinations of the single criteria are treated as multiobjective programming problems.

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