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Caesarean section delivery and childhood obesity: evidence from the growing up in New Zealand cohort.

Authors
  • Masukume, Gwinyai1, 2
  • McCarthy, Fergus P1, 2, 3
  • Russell, Jin4
  • Baker, Philip N5
  • Kenny, Louise C6
  • Morton, Susan Mb4
  • Khashan, Ali S7, 8
  • 1 INFANT Research Centre, Cork, Ireland. , (Ireland)
  • 2 Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland. , (Ireland)
  • 3 Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom. , (United Kingdom)
  • 4 Centre for Longitudinal Research - He Ara ki Mua, University of Auckland, Auckland, New Zealand. , (New Zealand)
  • 5 College of Life Sciences, University of Leicester, Leicester, United Kingdom. , (United Kingdom)
  • 6 Department of Women's and Children's Health, Institute of Translational Medicine, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom. , (United Kingdom)
  • 7 INFANT Research Centre, Cork, Ireland [email protected] , (Ireland)
  • 8 School of Public Health, Western Gateway Building, University College Cork, Cork, Ireland. , (Ireland)
Type
Published Article
Journal
Journal of Epidemiology & Community Health
Publisher
BMJ
Publication Date
Dec 01, 2019
Volume
73
Issue
12
Pages
1063–1070
Identifiers
DOI: 10.1136/jech-2019-212591
PMID: 31597672
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Epidemiological studies have reported conflicting results in the association between Caesarean section (CS) birth and childhood obesity. Many of these studies had small sample sizes, were unable to distinguish between elective/planned and emergency CS, and did not adjust for the key confounder maternal pre-pregnancy body mass index (BMI). We investigated the association between CS delivery, particularly elective/planned and childhood obesity, using the Growing Up in New Zealand prospective longitudinal cohort study. Pregnant women planning to deliver their babies on the New Zealand upper North Island were invited to participate. Mode of delivery was categorised into spontaneous vaginal delivery (VD) (reference), assisted VD, planned CS and emergency CS. The main outcome was childhood obesity defined according to the International Obesity Taskforce criteria at age 24 and 54 months. Multinomial logistic regression and mixed-effects linear regression models were fitted with associations adjusted for several potential confounders. Of the 6599 infants, 1532 (23.2%) were delivered by CS. At age 24 months, 478 (9.3%) children were obese. There was a statistically significant association between planned CS adjusted relative risk ratio (aRRR=1.59; (95% CI 1.09 to 2.33)) and obesity but not for emergency CS (aRRR=1.27; (95% CI 0.89 to 1.82)). At age 54 months there was no association between planned CS (aRRR=0.89; (95% CI 0.54 to 1.45)) and obesity as well as for emergency CS (aRRR=1.19; (95% CI 0.80 to 1.77)). At all-time points those born by planned CS had a higher mean BMI (adjusted mean difference=0.16; (95% CI 0.00 to 0.31), p=0.046). Planned CS was an independent predictor of obesity in early childhood. This suggests that birth mode influences growth, at least in the short term. This association occurred during a critical phase of human development, the first 2 years of life, and if causal might result in long-term detrimental cardiometabolic changes. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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