Affordable Access

Publisher Website

Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
55
Issue
1
Identifiers
DOI: 10.1016/0014-2999(79)90149-3
Keywords
  • Dopaminergic
  • Apomorphine
  • Rigid Analogs
  • 2-Aminotetralin
  • 2-Aminoindane

Abstract

Abstract A series of rigid analogs of apomorphine lacking aromatic hydroxyl substituents were evaluated for dopaminergic properties. Three compounds, N-methyl-N-propyl-2-aminotetralin (Me-Pr-2-AT), N, N-dipropyl-2-aminotetralin (Di-Pr-2-AT) and N, N-dipropyl-2-aminoindane (Di-Pr-2-AI) induced emesis in dogs, contralateral circling in unilaterally lesioned rats, and inhibited prolactin secretion. The induced circling responses, however, were attenuated by prior treatment with α-methyl-p-tyrosine methyl ester (AMPTME) and the compounds were weak inhibitors of 3H-dopamine binding in calf caudate homogenates. The posssiblity that these agents may be metabolically activated in vivo is discussed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments