Affordable Access

Publisher Website

Phase II Study of Paclitaxel, Cisplatin, and 5-Fluorouracil Combination Chemotherapy in Patients with Advanced Gastric Cancer

Journal of Korean Medical Science
Korean Academy of Medical Sciences (KAMJE)
Publication Date
DOI: 10.3346/jkms.2008.23.4.586
  • Original Article
  • Biology
  • Medicine


This phase II study evaluated the efficacy and safety of combination chemotherapy with paclitaxel, cisplatin, and 5-fluorouracil (5-FU) in advanced gastric cancer. Patients with histologically confirmed gastric adenocarcinoma were eligible for the study. Paclitaxel (175 mg/m2) and cisplatin (75 mg/m2) were given as a 1-hr intravenous infusion on day 1, followed by 5-FU (750 mg/m2) as a 24-hr continuous infusion for 5 days. This cycle was repeated every 3 weeks. Forty-five eligible patients (median age, 56 yr) were treated in this way. Of the 41 patients in whom efficacy was evaluable, an objective response rate (ORR) was seen in 51.2% (95% CI, 0.35-0.67), a complete response in two, and a partial response in 19 patients. The median progression free survival was 6.9 months (95% CI, 5.86-7.94 months), and the median overall survival was 12.7 months (95% CI, 9.9-15.5). The main hematological toxicity was neutropenia and greater than grade 3 neutropenia was observed in twelve patients (54%). Febrile neutropenia developed in three patients (6.8%). The major non-hematological toxicities were asthenia and peripheral neuropathy, but most of patients showed grade 1 or 2. In conclusion, combination chemotherapy with paclitaxel, cisplatin, and 5-FU is a promising regimen, and was well tolerated in patients with advanced gastric cancer.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Multicenter phase II study of weekly paclitaxel pl...

on Cancer Chemotherapy and Pharma... November 2007

Phase II study of weekly paclitaxel, cisplatin, an...

on Gastric cancer : official jour... October 2011

Multicenter phase II trial of S-1, paclitaxel and...

on Cancer Chemotherapy and Pharma... March 2011

A phase I study of triplet combination chemotherap...

on Japanese journal of clinical o... February 2013
More articles like this..