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Uracil Debases Pathogenic but Not Commensal Bacteria

Authors
Journal
Cell Host & Microbe
1931-3128
Publisher
Elsevier
Publication Date
Volume
13
Issue
5
Identifiers
DOI: 10.1016/j.chom.2013.04.013

Abstract

The metazoan gut harbors microbial communities on its mucosal surfaces, yet the mechanisms by which gut immunity tolerates symbiotic and commensal bacteria while eliminating pathogens is insufficiently understood. In a recent Cell paper, Lee et al. (2013) show that bacterial uracil, not secreted by commensal bacteria, triggers dual oxidase-dependent immunity.

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