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Calcium efflux and respiratory inhibition in brain mitochondria: Effects of chlorpromazine metabolites

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
48
Issue
1
Identifiers
DOI: 10.1016/0006-291x(72)90365-8

Abstract

Abstract 7-Hydroxychlorpromazine was found to be similar to chlorpromazine in its ability to inhibit brain mitochondrial calcium accumulation and respiration. 7,8-Dihydroxychlorpromazine, however, was found to produce a marked efflux of calcium accumulated by these mitochondrial preparations in the presence of ATP. In addition, this metabolite or one of its orthoquinone forms was observed to gradually inhibit state 4 respiration and prevent the stimulation of oxygen uptake normally observed upon the addition of phosphate and phosphate acceptor. The possible importance of sulfhydryl groups in these inhibitory actions is discussed.

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