Affordable Access

Publisher Website

Platelet prostaglandin E1hyposensitivity in schizophrenia: Reduction of prostaglandin E1- or forskolin-stimulated cyclic AMP response in platelets

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
45
Issue
22
Identifiers
DOI: 10.1016/0024-3205(89)90079-9

Abstract

Abstract Cyclic 3′, 5′ - adenosine monophosphate (cAMP) formation via prostaglandin E 1 (PGE 1)-or forskolin-stimulation were determined in washed intact platelets from 32 schizophrenic patients and 30 normal controls. Regarding basal cAMP levels in the platelets, there were no differences between schizophrenic patients and normal controls. Both PGE 1- and forskolin-stimulated cAMP response reduced in platelets from schizophrenics compared with normal controls. These results suggested that platelets in schizophrenics were impaired not only in the adenylate cyclase unit per se but also extensively in the cAMP generating system coupled to a PGE 1 receptor.

There are no comments yet on this publication. Be the first to share your thoughts.