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Solid and solution phase combinatorial synthesis of ureas

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
42
Identifiers
DOI: 10.1016/s0040-4039(98)01708-0

Abstract

Abstract An efficient parallel synthesis of ureas based on amino acids is described, both in solution and on solid phase. 1,1′-Carbonylbisbenzotriazole 2 is used as the coupling reagent. The ureas 5 and 10 were obtained in high yield (80–100%) and purity (71–97%).

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