Affordable Access

Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini.

Authors
  • Leite, M Fatima
  • Burgstahler, Angela D
  • Nathanson, Michael H
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Feb 01, 2002
Volume
122
Issue
2
Pages
415–427
Identifiers
PMID: 11832456
Source
Medline
License
Unknown

Abstract

Polarized Ca(i)2+ waves are induced in acinar cells by serial activation of apical InsP3Rs and then basolateral RyRs, and subcellular release of Ca2+ coordinates the actions of these 2 types of Ca2+ channels. This subcellular integration of Ca2+-release channels shows a new level of complexity in the formation of Ca(i)2+ waves.

Report this publication

Statistics

Seen <100 times