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Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini.

Authors
Type
Published Article
Journal
Gastroenterology
0016-5085
Publisher
Elsevier
Publication Date
Volume
122
Issue
2
Pages
415–427
Identifiers
PMID: 11832456
Source
Medline
License
Unknown

Abstract

Polarized Ca(i)2+ waves are induced in acinar cells by serial activation of apical InsP3Rs and then basolateral RyRs, and subcellular release of Ca2+ coordinates the actions of these 2 types of Ca2+ channels. This subcellular integration of Ca2+-release channels shows a new level of complexity in the formation of Ca(i)2+ waves.

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