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Ca(v)2.3 (alpha1E) Ca2+ channel participates in the control of sperm function.

Authors
  • Sakata, Yu
  • Saegusa, Hironao
  • Zong, Shuqin
  • Osanai, Makoto
  • Murakoshi, Takayuki
  • Shimizu, Yasufumi
  • Noda, Tetsuo
  • Aso, Takeshi
  • Tanabe, Tsutomu
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 10, 2002
Volume
516
Issue
1-3
Pages
229–233
Identifiers
PMID: 11959138
Source
Medline
License
Unknown

Abstract

To know the function of the Ca2+ channel containing alpha(1)2.3 (alpha1E) subunit (Ca(v)2.3 channel) in spermatozoa, we analyzed Ca2+ transients and sperm motility using a mouse strain lacking Ca(v)2.3 channel. The averaged rising rates of Ca2+ transients induced by alpha-D-mannose-bovine serum albumin in the head region of Ca(v)2.3-/- sperm were significantly lower than those of Ca(v)2.3+/+ sperm. A computer-assisted sperm motility assay revealed that straight-line velocity and linearity were greater in Ca(v)2.3-/- sperm than those in Ca(v)2.3+/+ sperm. These results suggest that the Ca(v)2.3 channel plays some roles in Ca2+ transients and the control of flagellar movement.

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