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Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

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BioMed Central
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PMC
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  • Research
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  • Biology

Abstract

1743-7075-3-20.fm ral ss BioMed CentNutrition & Metabolism Open AcceResearch Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction Gualberto Ruaño*1, Andreas Windemuth1, Mohan Kocherla1, Theodore Holford2, Maria Luz Fernandez3, Cassandra E Forsythe4, Richard J Wood3, William J Kraemer4 and Jeff S Volek4 Address: 1Genomas, Inc., 67 Jefferson St, Hartford, CT 06106, USA, 2Department of Biostatistics, Yale University School of Medicine, New Haven, CT 06520, USA, 3Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA and 4Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA Email: Gualberto Ruaño* - [email protected]; Andreas Windemuth - [email protected]; Mohan Kocherla - [email protected]; Theodore Holford - [email protected]; Maria Luz Fernandez - maria- [email protected]; Cassandra E Forsythe - [email protected]; Richard J Wood - [email protected]; William J Kraemer - [email protected]; Jeff S Volek - [email protected] * Corresponding author Abstract Background: Diets that restrict carbohydrate (CHO) have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction. Methods: We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced a small level of ketosis (CHO ~10% of total energy). A total of 27 single nucleotide polymorphisms (SNPs) were selected from 15 candidate genes involved in fat digestion/metabolism, intracellular glucose metabolism, lipoprotein remodelin

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