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Effects of aging on contributions of dietary fat and triiodothyronine treatment to lipogenic enzyme induction

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
0005-2760
Publisher
Elsevier
Publication Date
Volume
921
Issue
1
Identifiers
DOI: 10.1016/0005-2760(87)90168-8
Keywords
  • Lipogenic Enzyme
  • Aging
  • Malic Enzyme
  • Dietary Fat
  • Triiodothyronine
  • Mrna Translation
  • (Rat Liver)
Disciplines
  • Biology

Abstract

Abstract Although lipogenic enzyme inductions are reduced by fat feeding, this reduction decreases with aging and is particularly detectable in the case of acetyl-CoA carboxylase and fatty acid synthetase activities. On the other hand, the fat-dependent reductions of malic enzyme and acetyl-CoA carboxylase were consistently relieved by triiodothyronine (T 3) treatment. The effects of T 3 treatment on these enzyme inductions were greater in 10-month-old rats than in 1-month-old rats, while the carbohydrate-dependent induction and the fat-dependent reduction of the enzymes decreased with aging. In these animals, alterations in malic enzyme mRNA translational activities were roughly in parallel to the enzyme activities. Therefore, the age-dependent alterations in effects of T 3 treatment and fat on malic enzyme induction do not appear to occur in post-translation.

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