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Catecholamine metabolite excretion of infants with heart failure

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
69
Issue
2
Identifiers
DOI: 10.1016/s0022-3476(66)80329-3
Disciplines
  • Biology

Abstract

Twenty-four hour excretion of the catecholamine metabolites, normetanephrine and metanephrine (NMN+MN) and vanillyl-mandelic acid (VMA), was found to be elevated more than twofold in infants with severe heart failure, probably indicating augmented catecholamine biosynthesis. The role of catecholamines in the pathophysiology of heart failure is discussed. Infants with severe cyanosis rather than heart failure as the major problem showed a minor increase of NMN+MN excretion but not of VMA excretion.

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