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Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
29
Issue
18
Identifiers
DOI: 10.1016/0024-3205(81)90518-x

Abstract

Abstract Tosyl-L-lysyl chloromethyl ketone (TLCK), added to an incubation of rabbit reticulocytes, inhibits the synthesis of α globin chain more than that of β chain. TLCK has been previously shown to inhibit initiation of translation in a variety of cells. Thus this drug could be used to test for such a differential effect at the level of peptide initiation on the various mRNAs in these cells.

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