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Palladium-catalysed hydroxycarbonylation of vinyl and aryl triflates: synthesis of α,β-unsaturated and aromatic carboxylic acids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
33
Issue
27
Identifiers
DOI: 10.1016/s0040-4039(00)74824-6

Abstract

Abstract The palladium-catalysed hydroxycarbonylation of vinyl and aryl triflates, under a CO balloon, in the presence of potassium acetate affords α,β-unsaturated and aromatic carboxylic acids with one more carbon in good to high yield. The nature of the solvent and of the ligand have been proved to be crucial for the success of the reaction. Vinyl triflates undergo the hydroxycarbonylation at room temperature in DMF in the presence of Pd(OAc) 2(PPh 3) 2. Aryl triflates produce best results at 60 °C in DMSO in the presence of Pd(OAc) 2 and 1,1-bis (diphenylphosphino)ferrocene (dppf).

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