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Humn Bocavirus, a newly discovered Parvovirus of the respiratory tract

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  • Human Health Sciences :: Immunology & Infectious Disease [D12]
  • Sciences De La Santé Humaine :: Immunologie & Maladie Infectieuse [D12]
  • Biology
  • Medicine


Acta Clinica 293-354.indd Acta Clinica Belgica, 2008; 63-5 329HUMAN BOCAVIRUS HUMAN BOCAVIRUS, A NEWLY DISCOVERED PARVOVIRUS OF THE RESPIRATORY TRACT C. Ricour1, P. Goubau2 Key words: Bocavirus, emerging virus, children, respiratory sample, respiratory virus ––––––––––––––– 1 Université catholique de Louvain, Christian de Duve Institute, MIPA-VIRO Unit, avenue Hippocrate, 74/49, 1200 Bruxelles ; 2 Université catholique de Louvain, Laboratoire de virologie médicale, avenue Hippocrate, 54/92, 1200 Bruxelles, Belgium Address for Correspondencev: Goubau Patrick Laboratoire de Virologie UCL avenue Hippocrate 54/92 1200 Bruxelles Tel.: +32 (0)2 763 54 92 E-mail: [email protected] Case Report ABSTRACT Human Bocavirus is a newly discovered parvovi- rus. This virus is the fourth most frequently detected virus among symptomatic children with respiratory infection. Human Bocavirus is present worldwide and is a probable cause of symptomatic respira- tory infection, although Koch's postulates are not all fulfi lled. In this article, we propose an overview of the main clinical data about this virus, two years after its discovery. In addition, we discuss some hypotheses about its tropism for the lung in young children. In September 2005, Allander et al. identifi ed a new parvovirus in pooled nasopharyngeal aspirates (NPA) (1). From that time research groups (1-16) detected worldwide the new so-called Human Bocavirus (HBoV) by PCR in their sample collections. The prevalence of HBoV genome detection ranges from 1,5% (4) to 19% (13) among respiratory samples from symptomatic patients. With such a frequency the HBoV represents the fourth most frequently detected virus in respiratory samples (13,15). DESCRIPTION OF THE HUMAN BOCAVIRUS AND ITS FAMILY Human Bocavirus belongs to the genus Bocavirus in the Parvovirinae subfamily of the Parvoviridae family (better known as “parvovirus”). Thus far, only two other bocaviruses have been described: the Minu

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