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Micturition and defensive behaviors are controlled by distinct neural networks within the dorsal periaqueductal gray and deep gray layer of the superior colliculus of the rat

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
280
Issue
1
Identifiers
DOI: 10.1016/s0304-3940(99)00985-4
Keywords
  • Micturition
  • Freezing Behavior
  • Flight Behavior
  • Defense Reaction
  • Dorsal Periaqueductal Gray
  • Superior Colliculus
  • Logistic Threshold Analysis
Disciplines
  • Computer Science
  • Mathematics

Abstract

Abstract Electrical stimulation of the dorsal periaqueductal gray (DPAG) or the deep gray layer of the superior colliculus (DGSC) of rats placed in an open-field elicited either a display of tense immobility, accompanied by exophthalmus and/or defecation and micturition, or running and jumping responses. Threshold curves of each response were obtained for each structure by the logistic fitting of accumulated response frequencies. DPAG and DGSC threshold curves were compared by likelihood-ratio coincidence tests. The output of micturition was significantly higher following the stimulation of DPAG ( P<0.0005). In contrast, no differences were found for the remaining responses. These data support previous studies in anaesthetized cats suggesting the critical involvement of DPAG in the control of micturition. Furthermore, they also suggest that topographically distinct neural networks within the DPAG and DGSC control micturition and the other defensive behaviors.

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