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1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
10
Issue
20
Identifiers
DOI: 10.1016/s0960-894x(00)00454-6

Abstract

Abstract A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors. An indole with basic diamine moieties ( 12a) was the most potent thrombin inhibitor in the series with K ass=197 × 10 6 L/mol.

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