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Two new bacterial DNA primase inhibitors from the plantPolygonum cuspidatum

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
14
Issue
9
Identifiers
DOI: 10.1016/j.bmcl.2004.02.006
Disciplines
  • Biology

Abstract

Abstract The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC 50 of 4 and 5 μM, respectively.

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