Affordable Access

Publisher Website

Synthesis of enantiopure substituted aziridines by diastereoselectiveN-bromocyclization and nucleophile-mediated regioselective opening

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
30
Identifiers
DOI: 10.1016/s0040-4039(98)01109-5

Abstract

Abstract Enantiopure β-substituted aziridines were prepared from ( S)-phenylglycinol through a key N-bromocyclization of an unsaturated iminoether. A total control of the regioselectivity was observed during the opening of these aziridines by various nucleophiles (N 3 −, H 2O, EtOH, Me 2CuLi).

There are no comments yet on this publication. Be the first to share your thoughts.