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Effect of pertussis toxin treatment on the putative adenosine A3receptor-mediated hypotensive response in the rat

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
250
Issue
1
Identifiers
DOI: 10.1016/0014-2999(93)90641-t
Keywords
  • Adenosine A1Receptor
  • Adenosine A2Receptor
  • Adenosine A3Receptor
  • Pertussis Toxin
  • Apnea (N6-2-(4-Aminophenyl)Ethyladenosine)

Abstract

Abstract The effect of pertussis toxin pretreatment on the putative A 3 receptor-mediated hypotensive response to N 6-2-(4-aminophenyl) ethyladenosine (APNEA) has been investigated in the anaesthetised rat. Pertussis toxin pretreatment essentially abolished the bradycardia induced by the prototype A 1 receptor agonist, N 6-cyclopentyladenosine, whereas the fall in blood pressure induced by the selective A 2A receptor agonist, CGS 21680 was enhanced. Pertussis toxin substantially reduced the hypotensive response to APNEA. In this respect, the mechanism of action resembles that of the cloned A 3 receptor which when expressed in CHO cells couples negatively to adenylate cyclase by a pertussis toxin-sensitive mechanism. The data provide further evidence that adenosine A 3 receptors mediate the hypotensive response to APNEA in the rat.

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