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The Soluble Specific Substance of Pneumococcus: Second Paper

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Rockefeller University Press
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Disciplines
  • Medicine

Abstract

Avery's research on the specific soluble substance, or SSS, was an attempt to identify the substance that was responsible for the specific immunological reactions produced in pneumonia patients. Here, Avery and Heidelberger elaborated on their first paper (published in 1923) by indicating that they had improved the technique for the concentration and purification of SSS, and reported that distinct differences existed between the SSS of type-II and type-III pneumococci. The collaboration between Avery and Heidelberger initiated a line of research that yielded two articles, and, after Heidelberger left for Mount Sinai Hospital in 1924, several by Avery with Walther Goebel and F. H. Babers in the late 1920s.

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