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Histamine receptors in the human heart

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
26
Issue
26
Identifiers
DOI: 10.1016/0024-3205(80)90209-x

Abstract

Abstract Histamine receptor subtypes in in vitro isolated human coronary arteries and in in vitro human atrial and ventricular myocardium were studied. The H 1 receptor mediates contraction of coronary vascular smooth muscle but has no effect on atrial or ventricular tissue. The H 2 receptor mediates relaxation of human coronary artery vascular smooth muscle and mediates a positive inotropic response in atrial and ventricular myocardium.

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