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NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
525
Issue
1
Identifiers
DOI: 10.1016/0006-8993(90)91337-g
Keywords
  • N-Methyl-D-Aspartate
  • Long-Term Potentiation
  • Synaptic Plasticity
  • Piriform Cortex
  • Olfaction

Abstract

Abstract Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked induction of LTP in both pathways, indicating thatN-methyl- d-aspartate (NMDA) receptor activation is required for induction.

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