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Pluripotent Stem Cells - Methods and Protocols

PAGEPress Publications, Pavia, Italy
Publication Date
DOI: 10.4081/ejh.2013.br11
  • Book Review
  • Chemistry
  • Medicine
  • Philosophy


Hrev_master [European Journal of Histochemistry 2013; 57] [page 195] Pluripotent stem cells - Methods and proto-colsUma Lakshmipathy and Mohan C. Venturi(eds), 2013Springer protocolsMethods in Molecular Biology, vol. 997Humana press, Springer Verlag, HeidelbergISBN: 978-1-62703-347-3Pages: 292; Figures: 47; Color figures: 26; €114,39 The 2012 Nobel prize for Physiology or Medicine has been awarded conjunctely to Sir John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogram- med to become pluripotent, as during the syx- ties John Gurdon challenged the dogma that the specialised cell is irreversibly committed to its fate and just few years ago Shinya Yamanaka was the first to induce mature cells to reverse their development and turn back into induced pluripotent stem cells. This premium marks the avalanche of stu- dies that during this last decade has been car- ried out on all of the types of stem cells for several purposes (including translational medicine by cellular therapies based on stem cells) from basic research to grounded clinical therapies. These studies along the past few years highlight the substantial progress has been made in better defining (and in the understanding of) the stemness concept. This fact is something of particular value since the genetic epistemology that resides behing the stem cell definition is frequeltly used and abused to legiferate, to promise and sell to the market therapies and generally speaking to rise hypes and hopes at the inter- section of ethics, clinical therapies, science and law, funding basic research, granting patents, cloning and embryo status. Thus, it is particularly wellcome a book devoted to the basic of the pluripotent stem cells (the stem cells showing the great developmental plastici- ty) and detailing how to generate them (part I, seven chapters), to culture and to differentiate pluripotent stem cells (part II, six chapters), to characterize them (part III, five chapters) and finally on how to modify t

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