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How do immune response genes work?

Authors
Journal
Immunology Today
0167-5699
Publisher
Elsevier
Publication Date
Volume
1
Issue
2
Identifiers
DOI: 10.1016/0167-5699(80)90029-8

Abstract

Abstract Ir genes could operate either by controlling T-cell receptor repertoires, or by controlling antigen presentation to T cells. The idea that Ir genes are a germline set of V genes for T-cell receptors for foreign antigens can be excluded. Models involving indirect control of the T-cell receptor repertoire during somatic generation of diversity are still possible, though evidence from H-2 mutations suggests that the probability of their being correct is low. The idea that Ir genes control cell-surface MHC antigens that must associate closely with foreign antigens in the surface of antigen-presenting cells to cause T-cell activation is compatible with most, if not all of the available data.

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