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Development of Acid-Sensitive Platinum(II) Complexes With Protein-Binding Properties

Metal-Based Drugs
Publication Date
  • Biology


Four new protein-binding platinum(II) complexes, 10, 11, 21, 22, in which the dichloroplatinum moiety is coordinated either to a carbon-substituted or a nitrogen-substituted ethylene diamino ligand, were prepared in ten-step syntheses. According to pH-dependent stability studies with strictly related compounds, 11 and 22 exhibit acid-sensitive properties.

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