Affordable Access

Publisher Website

Epitope analysis: a strategy for intelligent mismatching in highly sensitized patients

Authors
Journal
Transplant Immunology
0966-3274
Publisher
Elsevier
Publication Date
Volume
2
Issue
2
Identifiers
DOI: 10.1016/0966-3274(94)90047-7
Disciplines
  • Medicine

Abstract

Abstract 1. 1) Analysis of nonreactivity in FRA lymphocytotoxicity assays allows the identification of ‘acceptable mismatches’. 2. 2) A few amino acid substitutions seem to account for 75% and 90% PRA in the sera from two patients, GH and ML. 3. 3) When the ‘acceptable mismatches’ of GH and ML were aligned against the ten most common HLA-A, B haplo-types in the UK, half were judged ‘acceptable’. 4. 4) In view of the ample opportunity for sensitization to two of these antigens (HLA-B7 and -B8) through a previous kidney rejected by GH these data suggest the existence of some form of programmed nonresponsiveness to common phenotypes. 5. 5) The tendency for recipient selection schemes to siphon off kidneys with common HLA phenotypes for beneficially matched nonsensitized recipients discriminates against HSPs. 6. 6) The imagined risk of transplanting kidneys with acceptable mismatches should prove groundless if nonreactivity can be clearly shown to be attributed to energy or tolerance.

There are no comments yet on this publication. Be the first to share your thoughts.