Affordable Access

Publisher Website

Cytotoxicity and DNA damage to mammalian cells by nitrofurans

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
16
Issue
2
Identifiers
DOI: 10.1016/0009-2797(77)90131-4

Abstract

Abstract Nitrofurazone, nitrofurantoin, furazolidone, furaltadone and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) were toxic to cultured mouse L cells. The extent of toxicity and the rate of reduction of nitrofurazone increased markedly as the oxygen content of the incubation medium was lowered. The toxic effect of nitrofurans was decreased by addition of serum and was much greater in phosphate-buffered saline containing glucose (PSG) than in medium. Damage to L cell DNA by nitrofurans increased as the oxygen concentration decreased from 21% to 0%. The concentration of nitrofurazone and duration of exposure also determined the number of DNA single-strand breaks. It is suggested that toxicity and DNA damage may result from the actions of toxic intermediates in the metabolic reduction of nitrofurans.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Cytotoxicity and DNA damage to mammalian cells by...

on Chemico-Biological Interaction... February 1977

Cytotoxicity of misonidazole and DNA damage in hyp...

on The British journal of cancer.... June 1978

DNA damage in mammalian cells.

on Free radical research communic... 1989
More articles like this..