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Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele

Authors
Publication Date
Volume
57
Issue
7
Identifiers
DOI: 10.1016/s0040-4020(00)01128-5
Keywords
  • Marine Metabolites
  • Sponges
  • Biologically Active Compounds
  • Enzyme Inhibitors

Abstract

Ancorinosides B-D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP). Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B-D inhibited MT1-MMP with IC values of 180-500 μg/mL. © 2001 Elsevier Science Ltd.

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