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Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
360
Issue
9329
Identifiers
DOI: 10.1016/s0140-6736(02)09521-1
Keywords
  • Primary Research
  • Research Letters
Disciplines
  • Medicine

Abstract

Summary Stereotactic radiosurgery is used to treat benign tumours, but its long-term effects are not fully understood. Here we describe a vestibular schwannoma that underwent malignant transformation 6 years after gamma knife radiosurgery applied to the tumour remnant after a primary resection. Histological specimens of the original specimen did not show any atypical features. Genotyping showed a TP53 mutation in the recurrent tumour, which did not exist in the original tumour. Our results suggest that radiosurgery induced the malignant transformation, and we propose a cautious application of this treatment for benign tumours.

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