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Synthetic strategies in combinatorial chemistry

Authors
Journal
Current Opinion in Chemical Biology
1367-5931
Publisher
Elsevier
Publication Date
Volume
1
Issue
1
Identifiers
DOI: 10.1016/s1367-5931(97)80107-x
Disciplines
  • Chemistry
  • Mathematics

Abstract

Abstract Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a ‘focused’ library involves conversion of a known synthetic route to the solid-phase or automated format, whereas generation of a ‘prospecting’ library is driven more by availability of input materials and considerations of structural novelty. While both types can be identified over the history of combinatorial chemistry, elaborating syntheses of novel, nonoligomeric, ‘drug-like’ molecules for use in prospecting libraries is a relatively recent development.

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