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Prospective Determination of Plasma Imipenem Concentrations in Critically Ill Children

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Pharmacology
Disciplines
  • Medicine

Abstract

Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4× at peak and >10× at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.

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