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Development and Validation of Spectrophotometric, Atomic Absorption and Kinetic Methods for Determination of Moxifloxacin Hydrochloride

Libertas Academica
Publication Date
  • Analytical Chemistry Insights
  • Volume: 2011
  • Issue: 6
  • Pharmacology


Analytical Chemistry Insights 2011:6 67–78 doi: 10.4137/ACI.S8090 This article is available from © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. Open Access Full open access to this and thousands of other papers at Analytical Chemistry Insights O r I g I n A L r e S e A r C h Analytical Chemistry Insights 2011:6 67 Development and Validation of spectrophotometric, Atomic Absorption and Kinetic Methods for Determination of Moxifloxacin Hydrochloride Lobna M. Abdellaziz1 and Mervat M. hosny2 1Medicinal Chemistry Department, Faculty of pharmacy, Zagazig University, egypt. 2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, egypt. Corresponding author email: [email protected] Abstract: Three simple spectrophotometric and atomic absorption spectrometric methods are developed and validated for the determination of moxifloxacin HCl in pure form and in pharmaceutical formulations. Method (A) is a kinetic method based on the oxidation of moxifloxacin HCl by Fe3+ ion in the presence of 1,10 o-phenanthroline (o-phen). Method (B) describes spectrophotometric procedures for determination of moxifloxacin HCl based on its ability to reduce Fe (III) to Fe (II), which was rapidly converted to the corresponding stable coloured complex after reacting with 2,2′ bipyridyl (bipy). The formation of the tris-complex formed in both methods (A) and (B) were carefully studied and their absorbance were measured at 510 and 520 nm respectively. Method (C) is based on the formation of ion- pair associated between the drug and bismuth (III) tetraiodide in acidic medium to form orange—red ion- pair associates. This associate can be quantitatively determined by three different procedures. The formed precipitate is either filtered off, dissolved in acetone and quantified spectr

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