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Effect of dietary palm olein oil on oxidative stress associated with ischemic-reperfusion injury in isolated rat heart

Authors
Publisher
BioMed Central
Publication Date
Source
PMC
Keywords
  • Research Article
Disciplines
  • Biology
  • Medicine

Abstract

1471-2210-4-29.fm ral ss BioMed CentBMC Pharmacology Open AcceResearch article Effect of dietary palm olein oil on oxidative stress associated with ischemic-reperfusion injury in isolated rat heart Deepak Narang1, Subeena Sood1, Mathew Kadali Thomas1, Amit Kumar Dinda2 and Subir Kumar Maulik*1 Address: 1Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India and 2Department of Pathology, All India Institute of Medical Sciences, New Delhi-110029, India Email: Deepak Narang - [email protected]; Subeena Sood - [email protected]; Mathew Kadali Thomas - [email protected]; Amit Kumar Dinda - [email protected]; Subir Kumar Maulik* - [email protected] * Corresponding author Abstract Background: Palm olein oil (PO), obtained from refining of palm oil is rich in monounsaturated fatty acid and antioxidant vitamins and is widely used as oil in diet in many parts of the world including India. Palm oil has been reported to have beneficial effects in oxidative stress associated with hypertension and arterial thrombosis. Oxidative stress plays a major role in the etiopathology of myocardial ischemic-reperfusion injury (IRI) which is a common sequel of ischemic heart disease. Antioxidants have potent therapeutic effects on both ischemic heart disease and ischemic-reperfusion injury. Information on the effect of PO on ischemic-reperfusion injury is, however, lacking. In the present study, the effect of dietary palm olein oil on oxidative stress associated with IRI was investigated in an isolated rat heart model. Wistar rats (150– 200 gm) of either sex were divided into three different groups (n = 16). Rats were fed with palm olein oil supplemented commercial rat diet, in two different doses [5% v / w (PO 5) and 10% v / w (PO 10) of diet] for 30 days. Control rats (C) were fed with normal diet. After 30 days, half the rats from each group were subjected to in vitro myocardial IRI (20 min of global ischemia, followed by

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