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The first total synthesis of iPF4α-VI and its deuterated analog

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
15
Identifiers
DOI: 10.1016/s0040-4039(02)00398-2
Keywords
  • Isoprostanes
  • Ip
  • Arachidonic Acid
  • Aa
  • Docosahexaenoic Acid
  • Dha
  • Ipf4α-Vi
  • D4-Ipf4α-Vi
Disciplines
  • Design

Abstract

Abstract The total and stereospecific syntheses of iPF 4α-VI and d 4-iPF 4α-VI have been accomplished. iPF 4α-VI is a docosahexanenoic acid (DHA)-derived isoprostane. DHA is the most abundant polyunsaturated fatty acid in the brain. Different synthetic designs have been used for the two syntheses. In the d 4-iPF 4α-VI design, the deuterated part of the molecule was introduced last in the synthesis.

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