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Binding of metal ions to polysaccharides. V.:Potentiometric, spectroscopic, and viscosimetric studies of the binding of cations to chondroitin sulfate and chondroitin in neutral and acidic aqueous media

Authors
Journal
Journal of Inorganic Biochemistry
0162-0134
Publisher
Elsevier
Publication Date
Volume
19
Issue
3
Identifiers
DOI: 10.1016/0162-0134(83)85026-0

Abstract

Abstract Binding of cations to chondroitin sulfate A and C, Chondroitin, and D-glucuronate was investigated in neutral and acidic aqueous media using H +, Cu 2+, and Na + ion-specific electrodes, viscometry, electron spin resonance (esr), and ligand-field spectroscopy. Site binding to the carboxylate group and only electrostatic interaction with the sulfate group could describe the results well. The nitrogen atom of the N-acetyl group appeared not to be involved in bonding of cations to chondroitin(sulfate) systems. The interaction of the divalent metal ions follows the Irving-Williams series. The value of the electrostatic potential at the carboxylate group of chondroitin(sulfate), as experienced by a cation, was determined in dependence of cation bonding. It proved to be difficult to establish the composition of a complex of a metal ion with a polyion by means of a molar ratio curve.

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