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Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1.

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  • Biology

Abstract

Universidade de São Paulo 2012 Modulation of Maternal Immune System During Pregnancy in the Cow REPRODUCTION IN DOMESTIC ANIMALS, HOBOKEN, v. 47, n. 2, pp. 384-393, AUG, 2012 http://www.producao.usp.br/handle/BDPI/33792 Downloaded from: Biblioteca Digital da Produção Intelectual - BDPI, Universidade de São Paulo Biblioteca Digital da Produção Intelectual - BDPI Departamento de Ciências Básicas - FZEA/ZAB Artigos e Materiais de Revistas Científicas - FZEA/ZAB Modulation of Maternal Immune System During Pregnancy in the Cow LJ Oliveira1, RSN Barreto1, F Perecin1, N Mansouri-Attia2, FTV Pereira3 and FV Meirelles1 1Department of Basic Sciences, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de Sa˜o Paulo, Pirassununga, SP, Brazil; 2Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA; 3Faculdade de Zootecnia, Universidade Estadual Paulista, Dracena, SP, Brazil Contents There is a molecular crosstalk between the trophoblast and maternal immune cells of bovine endometrium. The uterine cells are able to secrete cytokine ⁄ chemokines to either induce a suppressive environment for establishment of the pregnancy or to recruit immune cells to the endometrium to fight infections. Despite morphological differences between women and cows, mechanisms for immune tolerance during pregnancy seem to be conserved. Mechanisms for uterine immunesuppression in the cow include: reduced expression of major histocompat- ability proteins by the trophoblast; recruitment of macrophages to the pregnant endometrium; and modulation of immune- related genes in response to the presence of the conceptus. Recently, an eGFP transgenic cloned embryo model developed by our group showed that there is modulation of foetal proteins expressed at the site of syncytium formation, sug- gesting that foetal cell can regulate not only by the secretion of specific factors such as interferon-tau, but also by regulating their own protein expression to avoi

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