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Isolation and identification of 15-β-hydroxy cyproterone acetate as a new metabolite of cyproterone acetate in dog, monkey and man

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
30
Issue
3
Identifiers
DOI: 10.1016/0039-128x(77)90031-9

Abstract

Abstract 15-β-hydroxy cyproterone acetate could be identified by thin layer chromatography, mass spectrum, NMR and IR spectrum as a major unconjugated metabolite of cyproterone acetate in plasma and urine of dog, monkey and man. This metabolite has been found to interferein the Mattingly method for the determination of 11-hydroxy-corticosteroids which suggests, that this method is inadequate in controling the adrenal function of subjects treated with cyproterone acetate.

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