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Electro-Hyperthermia: A new Treatment in Oncology

Publication Date
  • Qc Physics / Fizika
  • Rc0254 Neoplasms. Tumors. Oncology (Including Cancer) / Daganatok
  • Tumorok
  • Onkológia
  • Rm Therapeutics. Pharmacology / Terápia
  • Gyógyszertan
  • Rz Other Systems Of Medicine / Orvostudomány Egyéb Területei
  • Biology
  • Medicine


Microsoft Word - WFSOS2001end.doc N.Szasz, O. Szasz, A. Szasz: Electro-Hyperthermia: A New Treatment in Oncology WFSOS Conference and 2nd Cancer Symposium, Napoli, Italy, September 19-22, 2001 S:\inwork\OWN Papers\3 Published\0 Publications - by years\Year 2001\WFSOS2001end.doc - 1 - Electro-Hyperthermia: A New Treatment in Oncology N. Szasz*, O. Szasz** and A. Szasz**, (*) Massachusetts Institute of Technology, Cambridge, MA, USA, (**) Szent Istvan University, Godollo, Hungary 2 Ibolya u., Paty, Hungary 2071, Tel: [36] (23) 555-510 Fax: [36] (23) 555-515 Email: [email protected] Objectives Although hyperthermia treatment in oncology is widely known, few consider it an effective mainstream treatment due to its negative effects. However, a new method, electro-hyperthermia, is capable of harnessing the advantages of hyperthermia, while reducing the negative effects that render most traditional hyperthermia treatments ineffective. This review will introduce electro-hyperthermia and compare it with the more traditional hyperthermia treatments. Background — Hyperthermia The effects of traditional hyperthermia are well known. Some of the more important advantages and disadvantages are summarized in Table 1. Table 1. Biological Effects of Traditional Hyperthermia [1] Positive Effects Negative Effects • Dividing cells (e.g. cancer cells), are more sensitive to heat, • Heat speeds up metabolism forcing tumors to use less efficient anaerobic pathways, • Low pH caused by anaerobic processes leads to acidosis, • Increased metabolism sensitizes the cells to chemo- and radiotherapy, • Hyperthermia primarily targets poorly oxygenated tissues thus complementing chemo- and radiotherapy. • Produces heat-shock proteins that protect the cells against damage, • May aid in the development of resistance against chemo- and/or radiotherapy, • May stimulate metastases formation, • Deep-heat delivery and focusing is a complex bioengine

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